Standard Lemma guide

agonist

noun · 7 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

Each Play button uses your device's default local English voice, or a natural local fallback. The selected voice name appears after playback. This is synthesized speech, not a source recording.

  • /ˈæɡəˌnɪst/
  • Southern-England: Recorded audio is listed in the source snapshot.
  • /ˈeɪ̯ɡəˌnɪst/ Upper Midwestern US, Northwestern US, Canada, æ-raising
  • CMU ARPABET: AE1 G AH0 N IH0 S T Digits mark lexical stress: 1 primary, 2 secondary, 0 unstressed.

1

noun

Meaning 1

Someone involved in a contest or battle (as in an agon), protagonist.

Definition source: English Wiktionary via Wiktextract

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

2

noun

Meaning 2

The muscle that contracts while the other relaxes.

Definition source: English Wiktionary via Wiktextract

Examples

  • When bending the elbow, the biceps is the agonist.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

3

noun

Meaning 3

A molecule that can combine with a receptor on a cell to produce a physiological reaction.

Definition source: English Wiktionary via Wiktextract

Topics: biochemistry, biology, chemistry, medicine, microbiology, natural-sciences, pharmacology, physical-sciences, sciences

Examples

  • Acetylcholine is an agonist at the cholinergic receptor.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

4

noun

Meaning 4

(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

Broader terms: drug

5

noun

Meaning 5

a muscle that contracts while another relaxes

Definition source: Princeton WordNet 3.0

Examples

  • when bending the elbow the biceps are the agonist

Meaning relationships

Synonyms: none provided

Antonyms: none provided

Broader terms: antagonistic muscle

6

noun

Meaning 6

someone involved in a contest or battle (as in an agon)

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: antagonist

Broader terms: contestant

7

noun

Meaning 7

the principal character in a work of fiction

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: protagonist

Antonyms: none provided

Broader terms: fictional character, fictitious character, character

Narrower terms: antihero

History

Etymology

Borrowed from Latin agōnista, from Ancient Greek ἀγωνιστής (agōnistḗs, “combatant, champion”). By surface analysis, agon or agony + -ist.

Across languages

Translations

18 source translations are retained for this English entry.

  • Finnish: taistelija — someone involved in a contest or battle
  • Polish: agonista — someone involved in a contest or battle
  • Polish: agonistka — someone involved in a contest or battle
  • Portuguese: agonista — someone involved in a contest or battle
  • Finnish: vaikuttajalihas — a muscle that contracts while another relaxes
  • Finnish: agonisti — a muscle that contracts while another relaxes
  • Indonesian: agonis — a muscle that contracts while another relaxes
  • Portuguese: agonista — a muscle that contracts while another relaxes
  • Chinese Mandarin: 激動劑 /激动剂 (jīdòngjì) — molecule that can combine with a receptor on a cell
  • Chinese Mandarin: 拮抗劑 /拮抗剂 (jiékàngjì) — molecule that can combine with a receptor on a cell
  • Czech: agonista — molecule that can combine with a receptor on a cell
  • Esperanto: agonisto — molecule that can combine with a receptor on a cell
  • Finnish: agonisti — molecule that can combine with a receptor on a cell
  • Indonesian: agonis — molecule that can combine with a receptor on a cell
  • Korean: 작용제 (jagyongje) — molecule that can combine with a receptor on a cell
  • Polish: agonista — molecule that can combine with a receptor on a cell
  • Portuguese: agonista — molecule that can combine with a receptor on a cell
  • Swedish: agonist — molecule that can combine with a receptor on a cell
Real reading context

agonist in complete knowledge articles