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Even the meekest or most docile people will retaliate or seek revenge if pushed too far.
Definition source: English Wiktionary via Wiktextract
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First attested in a collection of proverbs by John Heywood in 1546, in the form “Treade a worme on the tayle, and it must turne agayne.” Popularized by William Shakespeare in The Third Part of Henry the Sixth, see quotations.