Standard Lemma guide

holoprosencephaly

noun · 1 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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  • rhymes with -ɛfəli

1

noun

Meaning 1

A congenital disorder involving insufficient division of the lobes of the brain during fetal development, resulting in skull and facial deformities ranging from minor cleft lip problems to cyclopia, in which a single eye develops where the nose would normally be.

Definition source: English Wiktionary via Wiktextract

Usage: countable, uncountable

Topics: medicine, sciences, teratology

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

History

Etymology

From Ancient Greek ὅλος (hólos, “whole”) + πρόσω (prósō, “forwards, onwards”) (referring to the prosencephalon (“forebrain”)) + ἐγκέφαλος (enképhalos, “brain”) + English -y (suffix denoting a condition), i.e. “condition of a whole (inappropriately divided) forebrain”. By surface analysis, holo- + pros- + encephal- + -y.

Across languages

Translations

4 source translations are retained for this English entry.

  • Finnish: holoprosenkefalia — a congenital disorder involving insufficient division of the lobes of the brain
  • Polish: holoprozencefalia — a congenital disorder involving insufficient division of the lobes of the brain
  • Portuguese: holoprosencefalia — a congenital disorder involving insufficient division of the lobes of the brain
  • Portuguese: arrinencefalia — a congenital disorder involving insufficient division of the lobes of the brain