Standard Lemma guide

hydrochlorothiazide

noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

Each Play button uses your device's default local English voice, or a natural local fallback. The selected voice name appears after playback. This is synthesized speech, not a source recording.

  • General-American: /ˌhaɪ.dɹəˌklɔɹ.əˈθaɪ.əˌzaɪd/
  • General-American: Recorded audio is listed in the source snapshot.

1

noun

Meaning 1

A diuretic drug, with the chemical formula C7H8ClN3O4S2, that inhibits the kidneys' ability to retain water and lowers blood pressure.

Definition source: English Wiktionary via Wiktextract

Usage: countable, uncountable

Topics: chemistry, medicine, natural-sciences, organic-chemistry, pharmacology, physical-sciences, sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: tenzide

Antonyms: none provided

2

noun

Meaning 2

a diuretic drug (trade name Microzide, Esidrix, and HydroDIURIL) used in the treatment of hypertension

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Microzide, Esidrix, HydroDIURIL

Antonyms: none provided

Broader terms: thiazide

History

Etymology

Etymology tree Proto-Indo-European *wed- Proto-Indo-European *-r̥ Proto-Indo-European *wódr̥ Proto-Hellenic *údōr Ancient Greek ῡ̆̔́δωρ (hū̆́dōr) Ancient Greek ῠ̔δρο- (hŭdro-)der. English hydro- Proto-Indo-European *ǵhelh3- Proto-Hellenic *khlōrós Ancient Greek χλωρός (khlōrós) English chloro- Proto-Indo-European *dhewh2-der.? Ancient Greek θέειον (théeion) Ancient Greek θεῖον (theîon)der. English thio- Proto-Indo-European *né Proto-Indo-European *n̥- Proto-Hellenic *ə- Ancient Greek ᾰ̓- (ă-) Proto-Indo-European *gweyh3- Proto-Indo-European *-wós Proto-Indo-European *gwih3wós Proto-Indo-European *gwíh3weti Proto-Hellenic *gwyṓw-ō Proto-Hellenic *ďṓwō Ancient Greek ζώω (zṓō) Ancient Greek ζῶ (zô) Proto-Indo-European *-h2 Proto-Indo-European *-éh2 Ancient Greek -ᾱ (-ā) Ancient Greek -η (-ē) Ancient Greek ζωή (zōḗ) French azotebor. English az(ote) Proto-Indo-European *-nós Proto-Indo-European *-iHnos Proto-Italic *-īnos Latin -īnusder. Old French -inbor. Middle English -in English -ine English azine Proto-Indo-European *h2eḱ-der.? Ancient Greek ὀξύς (oxús) Proto-Indo-European *ǵenh1- Proto-Indo-European *-os Proto-Indo-European *ǵénh1os Proto-Hellenic *génos Ancient Greek γένος (génos) French oxygène Proto-Indo-European *h2eḱ- Proto-Indo-European *-éh1ti Proto-Indo-European *-yeti Proto-Indo-European *-éh1yeti Proto-Indo-European *h2eḱéh1yeti Proto-Italic *akēō Latin aceō Proto-Indo-European *dheh1-der. Proto-Italic *-iðos Latin -idus Latin acidusbor. French acide blend French oxidebor. English oxide Arabic لُبَان (lubān) Proto-Indo-European *yew- Proto-Indo-European *-os Proto-Indo-European *yéwos Proto-Indo-Iranian *yáwas Sanskrit यव (yava)bor.? Proto-Austronesian *zawa Proto-Malayo-Polynesian *zawader.? Old Javanese jawa Old Javanese -i Old Javanese Jawi Javanese ꦗꦮꦶ (jawi)der. Arabic جَاوَة (jāwa) Proto-Afroasiatic Proto-Semitic Arabic ـِيّ (-iyy) Arabic جَاوِيّ (jāwiyy) Arabic لُبَان جَاوِيّ (lubān jāwiyy)bor. Catalan benjuíder. Middle French benjoinder. English benzoin English benzo- English thia- Proto-Indo-European *dwóh1 Proto-Indo-European *dwi- Proto-Hellenic *dwi- Ancient Greek δῐ- (dĭ-)bor. Latin di-bor. English di- ▲ English azote ▲ English -ine English diazine English thiadiazine English benzothiadiazine ▲ English di- ▲ English oxide English dioxide blend English thiazide English -thiazide English hydrochlorothiazide From hydro- + chloro- + -thiazide.