Standard Lemma guide

hydroxyzine

noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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  • General-American: /haɪˈdɹɑk.səˌziːn/

1

noun

Meaning 1

A first-generation antihistamine of the piperazine class, used as an antihistamine, antiemetic, anxiolytic, and weak analgesic.

Definition source: English Wiktionary via Wiktextract

Usage: countable, uncountable

Topics: medicine, pharmacology, sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

2

noun

Meaning 2

a drug (trade names Atarax and Vistaril) used as a tranquilizer to treat anxiety and motion sickness

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: hydroxyzine hydrochloride, Atarax, Vistaril

Antonyms: none provided

Broader terms: minor tranquilizer, minor tranquillizer, minor tranquilliser, antianxiety drug, anxiolytic, anxiolytic drug

History

Etymology

Blend of hydroxy- + piperazine.