Standard Lemma guide

misfold

noun · verb · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

Each Play button uses your device's default local English voice, or a natural local fallback. The selected voice name appears after playback. This is synthesized speech, not a source recording.

  • Southern-England: Recorded audio is listed in the source snapshot.
  • /ˈmɪsfoʊld/
  • Southern-England: Recorded audio is listed in the source snapshot.
  • rhymes with -əʊld
  • /mɪsˈfoʊld/

1

noun

Meaning 1

An incorrect or abnormal folding.

Definition source: English Wiktionary via Wiktextract

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

2

verb

Meaning 2

To fold into an unusual or incorrect tertiary structure; misfolded proteins occur in various diseases, including amyloidoses and dementias, although the question of causation versus consequence is not yet definitively answered for dementias.

Definition source: English Wiktionary via Wiktextract

Usage: intransitive

Topics: biochemistry, biology, chemistry, microbiology, natural-sciences, physical-sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

History

Etymology

Etymology tree Proto-Indo-European *mey-? Proto-Indo-European *meyth2-der. Proto-Germanic *missaz Proto-Germanic *missa- Proto-West Germanic *missa- Old English mis- Middle English mys- English mis- English fold English misfold From mis- + fold.