Phrase guide

paroxysmal nocturnal hemoglobinuria

noun · 1 senses · updated from the 2026-07-25 local source snapshot

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1

noun

Meaning 1

A rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack protective surface proteins, making them vulnerable to complement-mediated destruction, leading to hemolysis, anemia, dark urine, and increased risk of blood clots.

Definition source: English Wiktionary via Wiktextract

Usage: uncountable

Topics: medicine, pathology, sciences

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Synonyms: none provided

Antonyms: none provided

History

Etymology

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