Phrase guide

patient zero

noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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No pronunciation record was provided for this word.

1

noun

Meaning 1

The initial patient in the population of an epidemiological investigation.

Definition source: English Wiktionary via Wiktextract

Topics: epidemiology, medicine, sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: index patient

Antonyms: none provided

Broader terms: patient

2

noun

Meaning 2

The source or origin of something.

Definition source: English Wiktionary via Wiktextract

Usage: figuratively, informal

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

History

Etymology

Originally patient O (standing for out of California), referring to Gaëtan Dugas, a superspreader of AIDS who was at the time erroneously believed to have introduced the virus to the United States. The letter O was later misinterpreted as a zero.