Phrase guide

Philadelphia chromosome

noun · 1 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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1

noun

Meaning 1

Human chromosome 22, after it has, pathologically, traded some of its genetic material with chromosome 9; this often causes chronic myelogenous leukemia.

Definition source: English Wiktionary via Wiktextract

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Ph chromosome

Antonyms: none provided

History

Etymology

The abnormality was first discovered and described in 1959 by David Hungerford from the Institute for Cancer Research and Peter Nowell from the University of Pennsylvania School of Medicine. Both facilities are located in Philadelphia, Pennsylvania.