Standard Lemma guide

rofecoxib

noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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  • General-American: /ˌɹoʊ.fəˈkɑk.sɪb/

1

noun

Meaning 1

A COX-2 inhibitor C17H14O4S (trademark Vioxx) used to relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis, to manage acute pain in adults, and to treat primary dysmenorrhea but withdrawn from sale by the manufacturer because of its link to cardiovascular events (as heart attack and stroke).

Definition source: English Wiktionary via Wiktextract

Usage: uncountable

Topics: medicine, pharmacology, sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

2

noun

Meaning 2

a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Vioxx

Antonyms: none provided

Broader terms: Cox-2 inhibitor

History

Etymology

From rofe- (of unknown origin) + -coxib (“selective cyclo-oxygenase inhibitor”).