Standard Lemma guide

senolytic

adj · noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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1

adj

Meaning 1

That destroys senescent cells.

Definition source: English Wiktionary via Wiktextract

Usage: not-comparable

Topics: medicine, sciences

Examples

  • 2022, Jacques Ferreira, Alex Deamer, Chapter 13: Clearance of senescent cells: potent anti-aging approach, Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra (editors), Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging, Elsevier (Academic Press), page 299, However, fisetin, a quercetin derivative, is moderately senolytic to many cell types, including mesenchyme-derived cells (Sasaki, Sato, & Nakanuma, 2020; Yousefzadeh et al., 2018), despite only differing by a hydroxyl group.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

2

noun

Meaning 2

Any drug that destroys senescent cells.

Definition source: English Wiktionary via Wiktextract

Topics: medicine, sciences

Examples

  • 2022, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Hang Lin, Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes, Zhen Li, Laura Creemers, Xiaoling Zhang (editors), Regenerative Medicine for Cartilage and Joint Repair, Frontiers in Bioengineering and Biotechnology, page 14, Therefore, the treatment with senolytics may not be able to reverse the loss of chondrogenic potential in PDL9.
  • 2023, Arda Küçükgüven, Íbrahim Vargel, 16: Antiaging: Is it possible?, Ibrahim Vargel, Fatma Figen Özgür (editor), Beauty, Aging and AntiAging, Elsevier (Academic Press), page 157, It is important to reevaluate the efficacy of these senolytics for long-term use in antiaging, particularly if they were originally developed for short-term use.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

History

Etymology

From seno- + -lytic.

Across languages

Translations

2 source translations are retained for this English entry.

  • German: senolytisch — that destroys senescent cells
  • German: Senolytikum — drug that destroys senescent cells