Standard Lemma guide

sertraline

noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

Each Play button uses your device's default local English voice, or a natural local fallback. The selected voice name appears after playback. This is synthesized speech, not a source recording.

  • Received-Pronunciation: /ˈsɜː.tɹəˌliːn/
  • General-American: /ˈsɜɹ.tɹəˌlin/
  • General-American: Recorded audio is listed in the source snapshot.
  • rhymes with -ɜː(ɹ)tɹəliːn

1

noun

Meaning 1

An antidepressant drug C17H17NCl2 administered in the form of its hydrochloride and acting to enhance serotonin activity.

Definition source: English Wiktionary via Wiktextract

Usage: uncountable

Topics: medicine, pharmacology, sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Zoloft

Antonyms: none provided

2

noun

Meaning 2

a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Zoloft)

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Zoloft

Antonyms: none provided

Broader terms: selective-serotonin reuptake inhibitor, SSRI

History

Etymology

From ser(otonin) + -traline (“serotonin reuptake inhibitor”).

Across languages

Translations

4 source translations are retained for this English entry.

  • French: sertraline — the antidepressant
  • Japanese: セルトラリン (serutorarin) — the antidepressant
  • Portuguese: sertralina — the antidepressant
  • Spanish: sertralina — the antidepressant