Standard Lemma guide

smoothened

adj · noun · verb · 4 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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1

adj

Meaning 1

Having been made smooth.

Definition source: English Wiktionary via Wiktextract

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: unsmoothened

2

noun

Meaning 2

A transmembrane protein belonging to the group of G protein-coupled receptors that is a key component of the hedgehog signaling pathway.

Definition source: English Wiktionary via Wiktextract

Usage: uncountable

Topics: biochemistry, biology, chemistry, microbiology, natural-sciences, physical-sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Smo

Antonyms: none provided

3

verb

Meaning 3

simple past and past participle of smoothen

Definition source: English Wiktionary via Wiktextract

Usage: form-of, participle, past

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

4

adjective satellite

Meaning 4

made smooth by ironing

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: smoothed

Antonyms: none provided

History

Etymology

From smoothen + -ed.

Ultimately the same as etymology 1. The gene encoding the protein was first identified in Drosophila melanogaster as a segment polarity gene and initially named smooth (smo) by Christiane Nüsslein-Volhard et al. in 1984. This was later revised to smoothened by Dan L. Lindsley and Georgianna G. Zimm in 1992, because the former name already described another locus.

Real reading context

smoothened in complete knowledge articles