Phrase guide

Tay-Sachs disease

noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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1

noun

Meaning 1

A rare genetic disorder in which harmful quantities of gangliosides accumulate in the brain's nerve cells.

Definition source: English Wiktionary via Wiktextract

Usage: uncountable

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: none provided

Antonyms: none provided

2

noun

Meaning 2

a hereditary disorder of lipid metabolism occurring most frequently in individuals of Jewish descent in eastern Europe; accumulation of lipids in nervous tissue results in death in early childhood

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Tay-Sachs, Sachs disease, infantile amaurotic idiocy

Antonyms: none provided

Broader terms: monogenic disorder, monogenic disease, autosomal recessive disease, autosomal recessive defect, lipidosis

History

Etymology

Named after British ophthalmologist Waren Tay and American neurologist Bernard Sachs.

Across languages

Translations

2 source translations are retained for this English entry.

  • Hungarian: Tay–Sachs-betegség — rare genetic disorder in which gangliosides accumulate in the brain's nerve cells
  • Portuguese: doença de Tay-Sachs — rare genetic disorder in which gangliosides accumulate in the brain's nerve cells