Standard Lemma guide

topoisomerase

noun · 1 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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  • Received-Pronunciation: /ˌtɒpəʊˌaɪˈsɒməˌɹeɪs/
  • General-American: /ˌtɑpoʊˌaɪˈsɑməˌɹeɪs/
  • US: Recorded audio is listed in the source snapshot.

1

noun

Meaning 1

Any of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.

Definition source: English Wiktionary via Wiktextract

Topics: biochemistry, biology, chemistry, microbiology, natural-sciences, physical-sciences

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: isotopomerase

Antonyms: none provided

History

Etymology

Etymology tree Ancient Greek τόπος (tópos) English topo- English isomer Proto-Indo-European *dwóh1 Proto-Indo-European *dwísder. Ancient Greek διά (diá) Ancient Greek δῐᾰ- (dĭă-) Proto-Indo-European *steh2- Proto-Indo-European *stísteh2ti Proto-Hellenic *hístāmi Ancient Greek ῐ̔́στημῐ (hĭ́stēmĭ) Ancient Greek δῐῐ̈́στημῐ (dĭĭ̈́stēmĭ) Ancient Greek δῐᾰ́στᾰσῐς (dĭắstăsĭs) English diastase English -ase English isomerase English topoisomerase From topo- + isomerase.

Across languages

Translations

2 source translations are retained for this English entry.

  • Chinese Mandarin: 拓扑异构酶 (tuòpū yìgòuméi) — enzymes that affect the topology of DNA
  • Finnish: topoisomeraasi — enzymes that affect the topology of DNA