Phrase guide

trisomy 21

noun · 2 senses · updated from the 2026-07-25 local source snapshot

Definitions and examples are grouped by meaning. Pronunciation, history, word forms, translations, descendants, synonyms, antonyms, derived terms, and related words appear whenever the source provides them.

Sound

Pronunciation

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No pronunciation record was provided for this word.

1

noun

Meaning 1

The presence of three copies of the 21st chromosome in the karyotype.

Definition source: English Wiktionary via Wiktextract

Usage: uncountable

Qualifier: medical genetics

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: Down syndrome

Antonyms: none provided

2

noun

Meaning 2

a congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation

Definition source: Princeton WordNet 3.0

No example sentence was provided for this meaning.

Meaning relationships

Synonyms: mongolism, mongolianism, Down's syndrome, Down syndrome

Antonyms: none provided

Broader terms: birth defect, congenital anomaly, congenital defect, congenital disorder, congenital abnormality, trisomy

History

Etymology

No etymology was provided for this word.

Across languages

Translations

8 source translations are retained for this English entry.

  • Chinese Mandarin: 21三体综合症 (èrshíyīsāntǐzōnghézhèng) — syndrome
  • Chinese Mandarin: 21三體綜合症 /21三体综合症 (èrshíyīsāntǐzōnghézhèng) — syndrome
  • French: trisomie 21 — syndrome
  • German: Trisomie 21 — syndrome
  • Polish: trisomia 21 — syndrome
  • Portuguese: trissomia 21 — syndrome
  • Portuguese: trissomia do 21 — syndrome
  • Russian: трисомия 21 (trisomija 21) — syndrome