Phrase guide

Tsuji-Trost reaction

noun · 1 senses · updated from the 2026-07-25 local source snapshot

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1

noun

Meaning 1

A palladium-catalysed substitution reaction involving a substrate that contains a leaving group in an allylic position. The palladium catalyst first coordinates with the allyl group and then undergoes oxidative addition, forming the π-allyl complex. This allyl complex can then be attacked by a nucleophile, resulting in the substituted product.

Definition source: English Wiktionary via Wiktextract

Topics: chemistry, natural-sciences, physical-sciences

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Meaning relationships

Synonyms: none provided

Antonyms: none provided

History

Etymology

Pioneered by Jiro Tsuji in 1965 and later adapted by Barry Trost in 1973 with the introduction of phosphine ligands.