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To innoculate with cowpox (the vacciolous virus) in order to produce immunity to smallpox.
Definition source: English Wiktionary via Wiktextract
Usage: archaic
No example sentence was provided for this meaning.
Meaning relationships
Synonyms: none provided
Antonyms: none provided
Coined in 1802 by Dr. John Walker, from vacciolous + -ate (verb-forming suffix).