Overview
Ciclindole (; developmental code name WIN-27,147-2), also known as cyclindole (), is an antipsychotic of the tetrahydrocarbazolamine family with a tricyclic cyclized tryptamine structure that was never marketed. It displaces spiperone binding in vitro and elevates dopamine levels in the striatum, indicating that it acts as a dopamine D 2 receptor antagonist. It also shows apparent affinity for the α 1 -adrenergic receptor, the serotonin S 1 receptor, and the serotonin S 2 receptor. However, its affinities for all of the preceding targets are weak, in the low micromolar range. The related drug flucindole is about 5 to 10times more potent than ciclindole both in vitro and in vivo.
See also
* Tetrahydrocarbazolamine * Cyclized tryptamine * Frovatriptan * α,N,N-Trimethyltryptamine * Iprindole