← Science & nature Science & nature · Advanced English

MNDA

Protein-coding gene in the species Homo sapiens

1 min
estimated reading 2
complete sections 16.17
algorithmic grade estimate

Before you read

Use the article and the local dictionary together

The complexity label is calculated from sentence length and syllable estimates; it is guidance, not an assessment of you. Open any highlighted word below for its full local dictionary page.

Words
95
Native text
869 characters
Dictionary match
61%
Revision
1301327417 · 2025-07-19T06:34:02Z
Key vocabulary

Words to check before reading

Differentiation2 uses in this article Antigen2 uses in this article encoded2 uses in this article Myeloid2 uses in this article Nuclear2 uses in this article region2 uses in this article human2 uses in this article significantly1 uses in this article participate1 uses in this article designated1 uses in this article expression1 uses in this article interferon1 uses in this article regulation1 uses in this article strikingly1 uses in this article suggesting1 uses in this article regulated1 uses in this article detected1 uses in this article response1 uses in this article element1 uses in this article exposed1 uses in this article

Overview

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.

Function

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Science & nature

Continue with related local reading

NephromaAdvanced Sternarchogiton zuanoniAdvanced Molecular sensorAdvanced Weather satelliteAdvanced DendriteAdvanced Bart BokAdvanced